Posts Tagged ‘Still’

Generics ? Still Controversial

The moment you use the word “generic” in the presence of someone employed by Big Pharma, there are reactions comparable to asking about contraceptives when visiting the Vatican. The reason is simple. The generic manufacturers are allowed to compete with the companies that went through the research and development phase after the patents have expired. All these “dangerous” companies need to do is to wait a few years and then copy all the original research. That means the product is bioequivalent and, under normal circumstances, the regulatory authorities in each country routinely licence the import of the copied drugs which are sold at a big discount. This affects the profits of Big Pharma. So, equally routinely, the lobbyists employed by Big Pharma discuss generic imports with their regulatory authorities, and sometimes those discussions lead to action. First, a word of reassurance. The action I am about to discuss does not affect your ability to buy generic viagra online. Although some thirty drugs are affected, they are treatments for rather different conditions. The FDA has issued two Warning Letters to Ranbaxy Laboratories Ltd, one of the world’s largest manufacturers of generic drugs based in India. These letters assert that Ranbaxy has not maintained proper manufacturing standards in two of its plants. Following the warnings, there is also an Import Alert that allows US customs officials to detain the finished drugs as they enter the US. These Warning Letters are somewhat controversial. There is no suggestion that the thirty drugs named on the list and manufactured in the identified plants are unsafe. There is no product recall and no warning to patients not to continue taking the drugs they already hold. Further, there is no suggestion that the other plants where different drugs are produced are unsafe in any way. This is, at best, a technical violation by the manufacturer. But the effect on Ranbaxy’s reputation has been quite chilling and its share price has fallen. To repeat, this does not affect the generic Viagra manufactured by Ranbaxy. The politics of free trade are always complicated. When the interests of significant local industrial players are involved, there is always going to be a temptation to be protectionist. In this instance, the decision of the FDA looks suspect because it has not required a recall. By its own admission, there is nothing wrong with the generic drugs manufactured by Ranbaxy. They can be safely consumed by existing patients. But the FDA is nevertheless authorising customs to stop imports of new supplies. I suspect that if the FDA had tried to interfere with the import of generic viagra, there would have been am outcry. As it is, there has been little comment outside the financial press discussing the effect on share price.

Blue Pill is Still Going Strong and Has Maximum Takers

About Viagra

Viagra, an oral therapy for erectile dysfunction, is the citrate salt of Sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). When the sexual stimulation causes local release of Nitric Oxide, inhibition of PDE5 by Sildenafil causes increased level of cGMP in the corpus cavernosum resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum.

Viagra is formulated as blue, film-coated rounded-diamond-shaped tablets and is one of the most commonly sold drug for treating male erectile dysfunction or impotence. It is also used for treating pulmonary arterial hypertension (PAH). The drug was developed by the pharmaceutical company Pfizer. Viagra is also informally known as “Vitamin V” or “the Blue Pill”.

Ingredients of Viagra

Viagra is contra-indicated in patients on nitrate therapy and with a known hypersensitivity to any ingredient of the tablet.

In addition to the active ingredient Sildenafil Citrate, each tablet contains the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and FD & C Blue #2 Aluminum Lake.

Comes in the strength of

Viagra pills are blue and diamond-shaped with the words “Pfizer” engraved on one side, and its dosage in milligrams engraved on the other side. The various doses of Sildenafil for erectile dysfunction are 25mg, 50mg and 100mg, taken not more than once per day between 30 minutes and 4 hours prior to sexual intercourse. It is usually recommended to start with a dosage of 50mg (or even 25mg) and then lower or raise the dosage as appropriate.

Side Effects of Viagra

Common side effects include:

Sneezing Headache Flushing Dyspepsia Palpitations; and/or Photophobia Priapism Severe hypotension Myocardial infarction Ventricular arrhythmias Stroke; and/or Increased intraocular pressure

Care should be exercised by patients who are also taking Protease inhibitors for the treatment of HIV. Patients using protease inhibitors must limit their use of Sildenafil to no more than one 25mg dose every 48 hours. Protease inhibitors inhibit the metabolism of Sildenafil, effectively multiplying the plasma levels and increasing the incidence and severity of side-effects.

Some Viagra users have also complained of blue vision (Cyanopsia), including blurriness and loss of peripheral vision. There is also the potential risk of sudden hearing loss associated with the use of PDE5 inhibitors. When used with an alpha blocker, hypotension (low blood pressure) may occur, but this effect does not occur if they are taken at least four hours apart.

Availability of Viagra

Buying Viagra can be safe, convenient, and affordable and is available at both online or offline pharmacies near you. Prior to buying Viagra online, always get a written prescription. Buy from a site that gives a street address and a telephone number. Better still, buy from a verified Internet Pharmacy Practice – a certified online pharmacy. Buying the generic version of the drug is ill-advised as it could be fake, illegal, or without proven safety or effectiveness record.

Amongst Viagra’s rare but serious adverse effects are:

Is Email Marketing Still Effective?

The golden question: is email marketing still effective? Are droves of prospective customers (both opt-in and solicited) reading your emails at a high rate and at high speeds? Well, this depends on what type of email you send. First, take a look at where email marketing is headed. It is a billion dollar a year industry, with about 65% companies of all types using 5-10% of their budget on email campaigns. Marketing with email is expected to yield more than 7 billion dollars this year. Companies are looking into buying ad space on widely circulated newsletters with tons of subscribers and email list vendors are earning big business. Lets look at the response rate of Marketing with email – the ultimate way to judge effectiveness!

Sadly enough, tons of unsolicited spam emails go unread. Through statistics, we’ve discovered that 5 to 15 percent of all e-mails are answered. Like the click through rates of banner advertisements at popular websites, spam emails are discarded like yesterday’s trash. A quick browse at the subject line ¨Free Viagra¨ and people are quick to press the delete button. Advertising is a very tricky medium – if your email campaign is not specifically targeted or if it does not employ creative and original strategies that lure customers, there will be a dead-end.

That said, unsolicited email (generic and commercial in nature) is usually not received by anyone. The likelihood of a person clicking on unsolicited mail is extremely low. In addition to the fact customers might not be interested in your offers in the first place, the margin for success is small!

If you have a relationship with the customer beforehand, email marketing can exceed boundaries. In order for email campaigns to work effectively, it must be solicited in the form of opt-in lists and permission. Adding a checkbox to your online store that says something along the lines of ¨send me periodic updates about your incoming shipments¨ for a customer to tick off fares better off in the marketing with email game. If you have customer permission to send them updates and newsletters with additional information, it will be well received!

Marketing with email is most effective with two-way communication. Unsolicited spam mail is considered a one-way message because it is chock full of advertisements that ask customers to visit websites and purchase products. It takes up their time without receiving any sort of compensation. Email marketing campaigns through opt-in lists are different – they are tailored towards the customer’s interest and garner higher response rates. Your email list is paramount as well. Back up your campaign by purchasing a list from a list vendor who offers email addresses that are willing to receive your advertisement. Each email address usually costs between 20 and 40 cents.

Newsletters and promotions combined together make for explosive campaigns. A well written, HTML formatted newsletter can boost traffic and generate sales. Promotions can initiate customers to buy a product that they are interested in. You see, the secret to an effective promotionb is the interaction between the customer and the business.

Notice the trend: unsolicited email appearing out of no where flooding your Inbox will not generate the same response as a newsletter an opt-in list member subscribed to. By exercising business/customer relations and gauging your customer’s needs, your email marketing will become more fruitful and lead to the dollars.

How do we determine whether an email marketing campaign is effective?

The bread & butter of a campaign is its’ ability to be opened and read. Unlike print material, email provides tracking tools to gauge visitor statistics and click through rates. A true email campaign will strive to seek as much customer data as possible. Add a response form to your emails or invite newsletter subscribers to join an online message board. Droves of customers registering to your online community can highlight your emails ability to attract. Add links to your newsletter and observe its click through rate with tracking software.

The savvy email marketer will investigate trends and tricks for time tested email campaigns. For instance, HTML format emails are more visually pleasing than plain text emails – run a campaign using both formats and see which gets the most click rates! Will offering discount couples for opt-in list subscribers do the trick? If you own an online store, run a promotion where subscribers can receive a code via email to use for discount purchases on your site! For example, a site selling pheromones, is currently offering 20% off anything on their product list for newsletter readers only. Not only does this encourage customers to purchase off your site, but also you’ll know who your loyal customers are.

Another way to determine whether your email campaign is off the charts or not is to compare what you’ve received from a special campaign with the amount of money you’ve spent. Is your discount sunglasses newsletter generating $100 a month off click throughs and on-the-spot purchases versus spending $12 on paying a freelance writer for article writing and $3 on target email addresses? If so, your email campaign is paying off! Are members of your opt-in list clicking more on Discount Coupons for All Purchases¨ than the title ¨The History of Sunglasses?¨ Discount coupons lead to big purchases, so try to launch promotional opportunities more often! A successful email campaign is measured by its personal interaction with customers. If customers are not responding well to your emails, try other strategies. Read and respond to consumer needs using trial & error and use tracking tools after every mailing to see how well you do.

Dan Farrell has been marketing online for several years and is offering his ebook, “Unlock Email Secrets” for free. If you are sending emails for fun or profit, you need to read these timely tips. Get his ebook by visiting:
Unlock Email Marketing Secrets

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